Cannabinoids, such as THC and CBD, are molecules produced by a cannabis plant. At the same time, endocannabinoids are the substances naturally produced by our bodies that respond to cannabinoids by stimulating receptors.. The cannabinoids act as the keys within the ECS, while receptors act like locks.
Cannabinoid Receptors
•Throughout the nervous system's connective network, you can find cannabinoid receptors, known as CB1 and CB2. CB1 receptors are mainly found in the CNS but also outside the CNS. At the same time, CB2 receptors are primarily located outside the CNS and play an essential role in the immune system. Many tissues and bodily systems contain both CB1 and CB2 receptors, thus making the range of their effects widespread. Researchers have theorized that there may be a third cannabinoid receptorCB1 and CB2 belong to a family of G-protein coupled receptors. These receptors are embedded in the cell membrane and can directly influence incoming signals. CB1/CB2 receptors are believed to be more plentiful than any other kind of receptor system.
CB1 receptors are densely located in brain regions such as the neocortex, hippocampus, basal ganglia, amygdala, striatum, cerebellum, and hypothalamus. These sections of our brains mediate a wide variety of high-order behavioral functions, including learning and memory, executive function decision making, sensory and motor responsiveness, emotional reactions, feeding, and other homeostatic processes.
By contrast, CB2 receptors are primarily found in immune cells, such as lymphocytes, leukocytes, and B cells.
CB2:Role breathing and heart rate
Involved in: Peripheral nerves, thyroid, uterus, pituitary gland, adrenal, reproductive organs, skeletal muscle, lungs, bone marrow, bone tissue, bladder pancreas, skin neurons, and gitract.
Studies have shown that people with PTSD, chronic pain, and phobias have fewer cb1 receptors, or these receptors have a weaker binding capacity
50% of pharmaceuticals use the general class G-coupled receptors; The drug can steal parts from other receptors, so you make fewer cannabinoid receptors.
CB2 is found in the immune system on natural killer cells, b cells, t cells, tonsils, spleen thymus and liver, cardio tissue, skin reproductive tissue, bone connective tissue, endocrine, pancreas, tumors, brain, pineal gland hypothalamus, pituitary gland, thyroid, thymus pancreas, ovary testes adrenal kidney and uterus.
They protect against osteoporosis, pain, chronic liver disease, neurodegeneration, metabolic disorders, inflammation, neuroinflammation, and drug addiction.
Endocannabinoids
They keep the ECS running smoothly and are only produced by our bodies when needed –when you consume cannabis.
Anandamide (AEA) is dubbed as the "bliss molecule," with its root "ananda" being a Sanskrit word for "happiness, pleasure, joy, and delight." It was also the first endocannabinoid to be discovered. AEA is a high-affinity, for CB1 receptors with very low activity at CB2 receptors.
·Types of CBD
·Full-Spectrum CBD
·Full-spectrum means it contains the whole plant, including tetrahydrocannabinol (THC). As per definition, the full plant extract includes flowers, THC, and all cannabinoids. The full-spectrum cannabinoids are legal under the Farm Bill. However, the government warned to maintain the THC level within 0.3%.
·Benefits
·Since it contains the whole plant, it offers various health benefits. Flowers and other types of cannabinoids have many therapeutic potentials to reduce anxiety and depression and enhance better sleep.
·Broad-Spectrum CBD
·Among the three major types of CBD, broad-spectrum is relatively new. It contains other kinds of cannabinoids but eliminates THC. Since it doesn't have any THC, it is legal under the Farm Bill. However, the federal government restricts retailers because of mislabeling of broad-spectrum CBD.
·Benefits
·Whether you want to take THC or not, a broad spectrum is suitable for everyone. It offers several health benefits, becoming increasingly popular among those who don't consume THC.
·Concerns
·One of the biggest concerns of broad-spectrum is it can be costly. Extracting THC is expensive, so consumers have to pay a high amount to consume this product. Apart from that, some companies also mislabel their products that don't contain THC, but in reality, theydo.
·Isolate CBD
As the name suggests, it's an isolated form of CBD that contains only a single cannabis extraction, such as CBD. Since Epidolex is an isolated CBD with medicinal properties used to treat pain and stress caused due to epilepsy or seizures, it's legalized .
Summary:
Humans have used the plant between 4-6 thousand years
The medicine comes from the female flower
Our bodies have an ECS System, as all mammals do.
Two forms of receptors CB1Receptor andCB2 receptors
The majority of CB1 receptors are in the brain
CB2 in other organs of the body. Primarily immune system PNS system
The healing abilities of the plant are outstanding.
